Having escaped years of imprisonment, vampire warrioress Selene finds herself in a changed world where humans have discovered the existence of both Vampire and Lycan clans and are conducting an all-out war to eradicate both immortal species. Now Selene must battle the humans and a frightening new breed of super Lycans to ensure the death dealers' survival. When human forces discover the existence of the Vampire and Lycan clans, a war to eradicate both species commences. The vampire warrior Selene leads the battle against humankind.